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Pseudomesotheliomatous carcinoma, lung

Definition: Rare peripheral adenocarcinoma clinically and macroscopically indistinguishable from malignant pleural mesothelioma, characterized by extensive pleural growth and little parenchymal involvement.
Diagnosis: Exclusively histological: the cells are D-PAS positive and react with anti-CEA, EMA, B72.3, and surfactant proteins antibodies. Ultrastructurally, neoplastic cells have the characteristics of type II pneumocytes.
Prognosis and Treatment: The aggressive behaviour is due probably to intrinsic properties of the tumor cells or to invasion of the pleural network.
Essential References:
   Dessy and Pietra: Pseudomesotheliomatous carcinoma of the lung. An immunohistochemical and ultrastructural study of three cases. Cancer 68(8):1747-1753,1991.


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Giuseppe G. Pietra: 16/12/2001 18:36:45




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