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(GLS - italian project)
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partially supported by

Rare breast tumors Senology Working Group

During the 2nd European Congress of Senology, held in Brussels in autumn 2000, a number of Lombard senologist surgeons felt the sharp and warm wish to establish a Working Group wholly dedicated to mammary pathology.
The idea of a “Senology Working Group” (“Gruppo di Lavoro in Senologia”, GLS) – this is the name they chose – was born in Lombardy, one of the most populated Italian regions, as well as one of the most important and productive regions from the scientific point of view, also for what concerning mammary pathology.
Under the aegis and with the scientific assent of the Lombard A.C.O.I. – Associazione Chirurghi Ospedalieri Italiani - (thanks to the will of its coordinator, Dr. F. Ferrante) and of the Regional Directive Council, such a Working Group aims at gathering all surgeons dealing with mammary pathology at their own institutions and individually unable, due to logistical reasons or to the scantiness of the pathologies they had the chance to treat, to produce or to express a scientific opinion.
The aim is unite all individual experiences, made of even a small number of cases which otherwise would remain scattered, in order to gather significant case histories. This way, everyone would take part in a single project, each with the same importance and the undeniable advantage of having one’s own work appreciated and enhanced. Once the statistically significant case histories are gathered, properly studied and discussed, the goal is to be able to express a reliable opinion in senological matters.

The first topic of work and study to be selected was that of rare breast tumors. A selection has been made in order to discriminate tumors occurring with a frequency between 1% and 10% from those occurring with a frequency lower than 1%, which can be dubbed unusual, or exceptional ones, of which the literature reports but a few occurrences.
The choice of the topic, “rare tumors”, was suggested by two reasons: a) the scarce knowledge we have of them, as it became evident from a survey of the literature (which presents reduced case histories, not allowing careful or conclusive analysis); b) the low frequency with which this topic is confronted during congresses.

The aim of the research is to uniform the clinical behaviours regarding these pathologies; for clear lines of conduct can be drawn only with pathologies occurring with considerable frequency. Otherwise, for what concerning exceptional or unusual pathologies, decisions have to be taken following contingent necessities, based on similarities with analogous cases which have already been observed or highlighted in the literature.
Rare histological types, listed below, must be taken into account only when they occur “pure” or “largely prevalent”, not in association with the most frequent ductal or lobular or mixed carcinoma.


Rare breast tumors here considered

Epithelial tumors
Invasive ductal carcinoma with a predominant intraductal component
Invasive intracystic carcinoma
Mucinous carcinoma
Medullary carcinoma
Invasive papillary carcinoma
Tubular carcinoma
Carcinoma with metaplasia
Carcinoma with endocrine differentiation
Paget disease of the nipple
Carcinoma of the male breast
Mixed connective tissue and epithelial neoplasms
Phyllodes tumor
Inflammatory carcinoma



The GLS sets itself the several tasks: cooperation with other working groups, widening to other specialists, involvement of other regions and possible promotion to a national level, resorting to Scientific Societies.
Once gathered and processed, the data will be published with the names of all participating centres. This project was started with care and enthusiasm, with the will to gather surgeons by choosing a topic that should be highly appealing to specialists; the idea is to establish a group expressing a vast geographical area and comprising colleagues of different provenance and specialization, sharing a common interest in senology.


For further information please contact the GLS secretary at this e-mail address:


or the secretaries:

- Dr. Massimo Grassi – P.O. Bassini – Cinisello B., Milano: 338/6736616
- Dr. Eugenio Di Sclafani – Ospedale FBF – Erba, Como: 335/5870321
- Dr. Giuliano Lucani – P.O. Salvini – Garbagnate, Milano: 335/461179
- Dr. Andrea Rusconi – C.C. San Pio X, Milano: 335/5847718